Submicroliter Liquid Handling 384 Wells at a Time

Liquid handling: dispensing reliability.

Measuring Liquid Volumes in Sub-nanoliter Wells

We are developing a method for high-throughput screening using arrays of “nanowells” built into a silicon substrate. These wells can serve as bioreactors for studying a variety of biochemical reactions such as the enzymatic activity that occurs in yeast metabolism. For a variety of studies it is important to know the volume of liquid that has been deposited in a given well and/or to monitor the...

Assay Assembly for Miniaturized Quantitative PCR in a 384-well Format using the Echo® Liquid Handler

Quantitative PCR (qPCR) has enabled a wide range of real-time applications including comparisons in gene expression, genotyping and SNP analysis. To ensure high data quality, the liquid handling employed in low-volume reactions must be exceptionally precise and accurate. This application note highlights the capabilities of the Echo 555 liquid handler to dispense into 384-well qPCR plates with t...

Probing liquid dynamics, one molecule at a time.

Viscous liquids are the precursors to glassy solids, a class of materials found in many important applications. Glasses are materials that have solidified via a gradual increase in viscosity, rather than by crystallization (1). As a result, understanding the dynamics of liquids near their glass transition temperature, Tg, will help create better noncrystalline solids and improve our knowledge o...

Laughlin-liquid-Wigner-solid transition at high density in wide quantum wells.

Assuming that the phase transition between the Wigner solid and the Laughlin liquid is first-order, we compare ground-state energies to find features of the phase diagram at fixed ν. Rather than use the Coulomb interaction, we calculate the effective interaction in a square quantum well, and fit the results to a model interaction with length parameter λ roughly proportional to the width of the ...